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James Hubbard

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James Hubbard

Biology Lab Coordinator
McFadden 206C
(817) 581-0534
jghubbard@txwes.edu
Website

Education:     

  • BS in Microbiology, UT Arlington, 1983
  • MS in Biology, UT Arlington, 1986
  • MS in Environmental Science, SMU, 2009

 Research Interests/Scholastic Profile:

Mr. Hubbard is currently responsible coordination and management of science laboratory activities to assist faculty in teaching and research endeavors.  Previous research revolved around the signaling and cytoskeletal elements responsible for cell division in Trypanosoma brucei.  Additional research focused on the use of transgenic and genetic models to examine the pathways involved in oxidative stress and aging in Drosophila melanogaster utilizing a multidisciplinary Molecular Biology approach.

 Courses taught at Texas Wesleyan:

  •  BIO 1121 – Intro to Cell Biology Lab
  •  NSC 1406 – Contemporary Biology Lab
Publications

Identification of a protein phosphatase 2A family member that regulates cell cycle progression in Trypanosoma brucei.  Rothberg KG, Jetton N, Hubbard JG, Powell DA, Pandarinath V, Ruben L.  Mole Biochem Parisitol. 2014 Mar-Apr; 194 (1-2).

The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms.  Jetton N, Rothberg KG, Hubbard JG, Wise J, Li Y, Ball HL, Ruben L.  Mol Microbiol. 2009 Apr;72(2):442-58.

The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis.  Regmi S, Rothberg KG, Hubbard JG, Ruben L.  Mol Microbiol. 2008 Nov;70(3):724-45.

Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster. Orr WC, Radyuk SN, Prabhudesai L, Toroser D, Benes JJ, Luchak JM, Mockett RJ, Rebrin I, Hubbard JG, Sohal RS.  J Biol Chem. 2005 Nov 11;280(45):37331-8.

Recombinant T Cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: dose effects and involvement of both CD4 and CD8 T cells.  KumarV, Over B, Hubbard G, Sercarz E, Wartd ES.  J Immunology 1997 Mar(159): 5150-5156.

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice.  Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES.  Eur. J. Immunol. 1996 Mar: 26(3):690-6.

The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn.  Popov S, Hubbard JG, Kim J, Ober B, Ghetie V, Ward ES.  Mol Immunol. 1996 Apr;33(6):521-30.

The dysfunction of coagulation factor VII Padua results from substitution of arginine-304 by glutamine.  James HL, Girolami A, Hubbard JG, Kumar A, Fair DS.  Biochem. Biophys. Acta.  1993 Mar 20:1172(3):301-5.

Molecular defect in coagulation factor X Friuli results from a substitution of serine for proline at position 343.  James HL, Girolami A, Hubbard JG, Fair DS.  Blood 1991 Jan 15: 77(2):317-23.

Isolation and characterization of the factor X Friuli variant.  Fair DS, Revak DJ, Hubbard JG, Girolami A.  Blood. 1989 Jun;73(8):2108-16.

Primary and Bacterial Secondary Production in a Southwestern Reservoir.  Chrzanowski TH, Hubbard JG.  Appl Environ Microbiol. 1988 Mar;54(3):661-669.

Impact of storms on heterotrophic activity of epilimnetic bacteria in a southwestern reservoir.  Hubbard JG, Chrzanowski TH.  Appl Environ Microbiol. 1986 Jun;51(6):1259-63.

Applicability of the fluorescein diacetate method of detecting active bacteria in freshwater.  Chrzanowski TH, Crotty RD, Hubbard JG, Welch RP.  Microbial Ecology  1984 June;10(2):179-85.